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. 2019 Sep 2;18:302. doi: 10.1186/s12936-019-2931-7

Table 3.

Association of microscopic and submicroscopic Plasmodium falciparum infection at delivery in maternal peripheral venous blood and placental blood with low birthweight, preterm birth and fetal growth restriction

Infection status % (N/N total) Adjusted odds ratio 95% confidence interval P
P. falciparum infection at delivery (peripheral blood)
 Low birthweighta (n = 1878)
  No infection 15.0 (272/1812)
  Submicroscopic infection 17.2 (5/29) 1.00 (0.35, 2.83) 0.99
  Microscopic infection 29.7 (11/37) 2.75 (1.27, 5.94) 0.010
 Preterm birthb (n = 1229)
  No infection 8.2 (97/1190)
  Submicroscopic infection 5.9 (1/17) 0.54 (0.07, 4.29) 0.56
  Microscopic infection 31.8 (7/22) 6.58 (2.46, 17.62) < 0.001
 Small for gestational agea (n = 1229)
  No infection 24.1 (287/1190)
  Submicroscopic infection 29.4 (5/17) 1.32 (0.44, 3.96) 0.63
  Microscopic infection 31.8 (7/22) 1.71 (0.67, 4.39) 0.26
P. falciparum infection at delivery (placental blood)
 Low birthweighta (n = 1272)
  No infection 13.8 (170/1228)
  Submicroscopic infection 28.6 (4/14) 2.85 (0.82, 9.91) 0.10
  Microscopic infection 30.0 (9/30) 2.08 (0.87, 4.98) 0.10
 Preterm birthb (n = 781)
  No infection 6.9 (52/749)
  Submicroscopic infection 18.2 (2/11) 3.34 (0.66, 16.83) 0.15
  Microscopic infection 19.1 (4/21) 3.04 (0.89, 10.3) 0.08
 Small for gestational agea (n = 781)
  No infection 21.4 (160/749)
  Submicroscopic infection 36.4 (4/11) 2.60 (0.71, 9.56) 0.15
  Microscopic infection 33.3 (7/21) 1.62 (0.61, 4.34) 0.34

a Adjusted for treatment arm, gender of the baby, gravidity, number of study visits, enrolment clinic, bed net use, nutritional status, stunting, socio-economic status and timing of birthweight measurement

b Adjusted for treatment arm, gender of the baby, gravidity, number of study visits, enrolment clinic, bed net use, nutritional status, stunting, and socio-economic status