Table 3.
Association of microscopic and submicroscopic Plasmodium falciparum infection at delivery in maternal peripheral venous blood and placental blood with low birthweight, preterm birth and fetal growth restriction
Infection status | % (N/N total) | Adjusted odds ratio | 95% confidence interval | P |
---|---|---|---|---|
P. falciparum infection at delivery (peripheral blood) | ||||
Low birthweighta (n = 1878) | ||||
No infection | 15.0 (272/1812) | |||
Submicroscopic infection | 17.2 (5/29) | 1.00 | (0.35, 2.83) | 0.99 |
Microscopic infection | 29.7 (11/37) | 2.75 | (1.27, 5.94) | 0.010 |
Preterm birthb (n = 1229) | ||||
No infection | 8.2 (97/1190) | |||
Submicroscopic infection | 5.9 (1/17) | 0.54 | (0.07, 4.29) | 0.56 |
Microscopic infection | 31.8 (7/22) | 6.58 | (2.46, 17.62) | < 0.001 |
Small for gestational agea (n = 1229) | ||||
No infection | 24.1 (287/1190) | |||
Submicroscopic infection | 29.4 (5/17) | 1.32 | (0.44, 3.96) | 0.63 |
Microscopic infection | 31.8 (7/22) | 1.71 | (0.67, 4.39) | 0.26 |
P. falciparum infection at delivery (placental blood) | ||||
Low birthweighta (n = 1272) | ||||
No infection | 13.8 (170/1228) | |||
Submicroscopic infection | 28.6 (4/14) | 2.85 | (0.82, 9.91) | 0.10 |
Microscopic infection | 30.0 (9/30) | 2.08 | (0.87, 4.98) | 0.10 |
Preterm birthb (n = 781) | ||||
No infection | 6.9 (52/749) | |||
Submicroscopic infection | 18.2 (2/11) | 3.34 | (0.66, 16.83) | 0.15 |
Microscopic infection | 19.1 (4/21) | 3.04 | (0.89, 10.3) | 0.08 |
Small for gestational agea (n = 781) | ||||
No infection | 21.4 (160/749) | |||
Submicroscopic infection | 36.4 (4/11) | 2.60 | (0.71, 9.56) | 0.15 |
Microscopic infection | 33.3 (7/21) | 1.62 | (0.61, 4.34) | 0.34 |
a Adjusted for treatment arm, gender of the baby, gravidity, number of study visits, enrolment clinic, bed net use, nutritional status, stunting, socio-economic status and timing of birthweight measurement
b Adjusted for treatment arm, gender of the baby, gravidity, number of study visits, enrolment clinic, bed net use, nutritional status, stunting, and socio-economic status