Table 1.

Association of Notch1 expression with clinicopathological factors of the HCC patients in cohort I and cohort II

Clinicopathological variables		Cohort I				Cohort II
		n	Notch1 expression		aP value	n	Notch1 expression		aP value
			Low (n = 75)	High (n = 75)			Low (n = 36)	High (n = 31)
Sex	Male	122	61	61	1.000	54	31	23	0.219
	Female	28	14	14		13	5	8
Age, years	≤ 50	63	35	28	0.247	38	17	21	0.091
	>  50	87	40	47		29	19	10
Serum AFP, ng/mL	≤ 20	63	33	30	0.620	23	12	11	0.853
	>  20	87	42	45		44	24	20
Tumor nodule number	Solitary	123	60	63	0.524	52	28	24	0.972
	Multiple	27	15	12		15	8	7
Maximal tumor size, cm	≤ 5	69	35	34	0.870	37	21	16	0.581
	>  5	81	40	41		30	15	15
Microvascular invasion	Absent	68	40	28	0.049	39	24	15	0.130
	Present	82	35	47		28	12	16
Tumor differentiation	Well	19	9	10	0.806	22	14	8	0.256
	Moderately or poorly	131	66	65		45	22	23
TNM stage	I and II	97	49	48	0.864	47	26	21	0.689
	III and IV	53	26	27		20	10	10

^a Pearson chi-square test was used for comparison between subgroups. Significant results (P < 0.05) are given in bold