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. 2019 Aug 14;8(8):303. doi: 10.3390/antiox8080303

Table 2.

Sensitization of doxorubicin-resistant human ovarian adenocarcinoma cell line by silychristin A and its derivatives expressed as IC50.

IC50 [µM] HOC HOC/ADR
Silychristin A 144 ± 2 184 ± 5
2,3-Dehydrosilychristin A 50.8 ± 0.9 68 ± 9
Isosilychristin 209 ± 3 115 ± 4
Anhydrosilychristin 45 ± 4 66 ± 3
Doxorubicin 0.022 ± 0.001 6.2 ± 0.3

Data are expressed as the concentration (µM) that halved the growth of the population (IC50) of the sensitive human ovarian adenocarcinoma cell (HOC) and doxorubicin-resistant HOC/ADR cell lines.