Table 3.

Doxorubicin-sensitization rate of doxorubicin-resistant human ovarian carcinoma cells (HOC/ADR) co-cultivated with the presence of silychristin derivatives.

Compound	10 µM	20 µM
Silychristin A	(1.7 ± 0.2) ×	(4.0 ± 0.2) ×
2,3-Dehydrosilychristin A	(1.3 ± 0.1) ×	(4.8 ± 0.3) ×
Isosilychristin	(1.0 ± 0.1) ×	(1.5 ± 0.1) ×
Anhydrosilychristin	(1.5 ± 0.1) ×	(1.0 ± 0.0) ×

The sensitization rate was determined as the ratio of doxorubicin IC₅₀ and doxorubicin + derivatives IC₅₀.