Table A1.
Comparison of ABC (ATP-binding cassette) superfamily genes expression profiles in doxorubicin-sensitive HOC and -resistant HOC/ADR cell lines.
| Gene Symbol | Assay ID | GenBank Accession No. | Gene Name | Amplicon Length (bp) | Expression Difference | P | Resistant versus Sensitive |
|---|---|---|---|---|---|---|---|
| Reference | |||||||
| PPIA | Hs99999904_m1 | NM_021130.3 | Peptidylprolyl isomerase A | 98 | |||
| Target | |||||||
| ABCA1 | Hs00194045_m1 | NM_005502.3 | ABC, sub-family A (ABC1), member 1 | 125 | 3.140 | 0.000 | overexpression |
| ABCA2 | Hs00242232_m1 | NM_212533.2 | ABC, sub-family A (ABC1), member 2 | 58 | 1.402 | 0.000 | overexpression |
| ABCA3 | Hs00184543_m1 | NM_001089.2 | ABC, sub-family A (ABC1), member 3 | 77 | 0.487 | 0.161 | |
| ABCA4 | Hs00184367_m1 | NM_000350.2 | ABC, sub-family A (ABC1), member 4 | 71 | neither in HOC nor in HOC/ADR | ||
| ABCA5 | Hs00363322_m1 | NM_172232.2 | ABC, sub-family A (ABC1), member 5 | 100 | 4.595 | 0.000 | overexpression |
| ABCA6 | Hs00365329_m1 | NM_080284.2 | ABC, sub-family A (ABC1), member 6 | 83 | neither in HOC nor in HOC/ADR | ||
| ABCA7 | Hs00185303_m1 | NM_019112.3 | ABC, sub-family A (ABC1), member 7 | 80 | 2.632 | 0.000 | overexpression |
| ABCA8 | Hs00992371_m1 | NM_007168.2 | ABC, sub-family A (ABC1), member 8 | 85 | neither in HOC nor in HOC/ADR | ||
| ABCA9 | Hs00329320_m1 | NM_080283.3 | ABC, sub-family A (ABC1), member 9 | 145 | neither in HOC nor in HOC/ADR | ||
| ABCA10 | Hs00365268_m1 | NM_080282.3 | ABC, sub-family A (ABC1), member 10 | 127 | neither in HOC nor in HOC/ADR | ||
| ABCA12 | Hs00292421_m1 | NR_103740.1 | ABC, sub-family A (ABC1), member 12 | 77 | neither in HOC nor in HOC/ADR | ||
| ABCA13 | Hs01110169_m1 | NM_152701.3 | ABC, sub-family A (ABC1), member 13 | 80 | neither in HOC nor in HOC/ADR | ||
| ABCB1 | Hs00184491_m1 | NM_000927.4 | ABC, sub-family B (MDR/TAP), member 1 | 110 | no detectable level of expression in HOC | ||
| ABCB2 | Hs00388677_m1 | NM_000593.5 | Transporter 1, ABC, sub-family B (MDR/TAP) | 60 | 0.263 | 0.320 | not affected |
| ABCB3 | Hs00241060_m1 | NM_018833.2 | Transporter 2, ABC, sub-family B (MDR/TAP) | 66 | 0.290 | 0.000 | attenuated |
| ABCB4 | Hs00240956_m1 | NM_018850.2 | ABC, sub-family B (MDR/TAP), member 4 | 73 | neither in HOC nor in HOC/ADR | ||
| ABCB6 | Hs00180568_m1 | NM_005689.2 | ABC, sub-family B (MDR/TAP), member 6 | 60 | 4.339 | 0.000 | overexpression |
| ABCB7 | Hs00188776_m1 | NM_004299.3 | ABC, sub-family B (MDR/TAP), member 7 | 92 | 1.485 | 0.320 | not affected |
| ABCB8 | Hs00185159_m1 | NM_007188.3 | ABC, sub-family B (MDR/TAP), member 8 | 74 | 1.611 | 0.000 | overexpression |
| ABCB9 | Hs00608640_m1 | NM_203444.2 | ABC, sub-family B (MDR/TAP), member 9 | 75 | 1.185 | 0.000 | overexpression |
| ABCB10 | Hs00429240_m1 | NM_012089.2 | ABC, sub-family B (MDR/TAP), member 10 | 133 | 1.270 | 0.000 | overexpression |
| ABCB11 | Hs00184824_m1 | NM_003742.2 | ABC, sub-family B (MDR/TAP), member 11 | 63 | neither in HOC nor in HOC/ADR | ||
| ABCC1 | Hs00219905_m1 | NM_004996.3 | ABC, sub-family C (CFTR/MRP), member 1 | 74 | 1.241 | 0.000 | overexpression |
| ABCC2 | Hs00166123_m1 | NM_000392.3 | ABC, sub-family C (CFTR/MRP), member 2 | 75 | 399.968 | 0.000 | overexpression |
| ABCC3 | Hs00358656_m1 | NM_003786.3 | ABC, sub-family C (CFTR/MRP), member 3 | 98 | neither in HOC nor in HOC/ADR | ||
| ABCC4 | Hs00195260_m1 | NM_005845.3 | ABC, sub-family C (CFTR/MRP), member 4 | 86 | 1.326 | 0.000 | overexpression |
| ABCC5 | Hs00981089_m1 | NM_005688.2 | ABC, sub-family C (CFTR/MRP), member 5 | 68 | 1.619 | 0.000 | overexpression |
| ABCC6 | Hs00184566_m1 | NM_001171.5 | ABC, sub-family C (CFTR/MRP), member 6 | 56 | 0.941 | 0.000 | attenuated |
| ABCC9 | Hs00245832_m1 | NM_020297.2 | ABC, sub-family C (CFTR/MRP), member 9 | 70 | neither in HOC nor in HOC/ADR | ||
| ABCC10 | Hs00675716_m1 | NM_033450.2 | ABC, sub-family C (CFTR/MRP), member 10 | 142 | 2.591 | 0.000 | overexpression |
| ABCD1 | Hs00163610_m1 | NM_000033.3 | ABC, sub-family D (ALD), member 1 | 101 | 4.417 | 0.000 | overexpression |
| ABCD2 | Hs00193054_m1 | NM_005164.3 | ABC, sub-family D (ALD), member 2 | 109 | 0.830 | 0.502 | not affected |
| ABCD3 | Hs00161065_m1 | NM_002858.3 | ABC, sub-family D (ALD), member 3 | 91 | 1.697 | 0.159 | not affected |
| ABCD4 | Hs00245534_m1 | NM_005050.3 | ABC, sub-family D (ALD), member 4 | 117 | 0.964 | 0.842 | not affected |
| ABCE1 | Hs01009190_m1 | NM_001040876.1 | ABC, sub-family E (OABP), member 1 | 91 | 1.207 | 0.000 | overexpression |
| ABCF1 | Hs00153703_m1 | NM_001090.2 | ABC, sub-family F (GCN20), member 1 | 69 | 1.706 | 0.000 | overexpression |
| ABCF2 | Hs00606493_m1 | NM_005692.4 | ABC, sub-family F (GCN20), member 2 | 113 | 1.330 | 0.000 | overexpression |
| ABCF3 | Hs00217977_m1 | NM_018358.2 | ABC, sub-family F (GCN20), member 3 | 61 | 1.792 | 0.000 | overexpression |
| ABCG1 | Hs00245154_m1 | NM_207629.1 | ABC, sub-family G (WHITE), member 1 | 58 | 2.532 | 0.000 | overexpression |
| ABCG2 | Hs00184979_m1 | NM_004827.2 | ABC, sub-family G (WHITE), member 2 | 92 | 0.467 | 0.000 | attenuated |
| ABCG4 | Hs00223446_m1 | NM_001142505.1 | ABC, sub-family G (WHITE), member 4 | 93 | 24.936 | 0.000 | overexpression |
| ABCG8 | Hs00223690_m1 | NM_022437.2 | ABC, sub-family G (WHITE), member 8 | 63 | neither in HOC nor in HOC/ADR | ||