Table A2.
Effect of silychristin A and its derivatives [10 µM] on ABC superfamily genes expression profiles in HOC/ADR cell line.
| Silychristin A | 2,3-Dehydrosilychristin A | Isosilychristin | Anhydrosilychristin | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene Symbol | Expression Difference | P | Treated versus Untreated | Expression Difference | P | Treated versus Untreated | Expression Difference | P | Treated versus Untreated | Expression Difference | P | Treated versus Untreated |
| PPIA | 1.000 | 1.000 | 1.000 | 1.000 | ||||||||
| ABCA1 | 1.217 | 0.321 | 0.801 | 0.000 | DOWN | 0.856 | 0.665 | 0.948 | 0.672 | |||
| ABCA2 | 0.755 | 0.000 | DOWN | 0.756 | 0.000 | DOWN | 0.743 | 0.000 | DOWN | 0.675 | 0.000 | DOWN |
| ABCA3 | 0.971 | 0.829 | 0.834 | 0.000 | DOWN | 0.755 | 0.336 | 0.686 | 0.000 | DOWN | ||
| ABCA5 | 0.971 | 0.829 | 0.965 | 0.675 | 0.864 | 0.499 | 0.822 | 0.341 | ||||
| ABCA7 | 1.220 | 0.172 | 1.241 | 0.000 | UP | 1.142 | 0.166 | 1.054 | 0.846 | |||
| ABCB1 | 0.932 | 0.321 | 0.863 | 0.654 | 0.796 | 0.000 | DOWN | 0.722 | 0.000 | DOWN | ||
| ABCB2 | 0.980 | 0.657 | 0.825 | 0.347 | 0.753 | 0.166 | 0.546 | 0.000 | DOWN | |||
| ABCB3 | 1.007 | 0.828 | 0.902 | 0.832 | 0.962 | 0.669 | 0.693 | 0.000 | DOWN | |||
| ABCB6 | 0.799 | 0.000 | DOWN | 0.707 | 0.000 | DOWN | 0.758 | 0.166 | 0.557 | 0.000 | DOWN | |
| ABCB7 | 0.855 | 0.321 | 0.735 | 0.157 | 0.769 | 0.166 | 0.820 | 0.174 | ||||
| ABCB8 | 0.833 | 0.000 | DOWN | 0.811 | 0.328 | 0.953 | 0.665 | 0.554 | 0.000 | DOWN | ||
| ABCB9 | 0.924 | 0.657 | 0.743 | 0.000 | DOWN | 0.848 | 0.000 | DOWN | 0.590 | 0.000 | DOWN | |
| ABCB10 | 0.883 | 0.657 | 0.774 | 0.157 | 0.626 | 0.166 | 0.568 | 0.000 | DOWN | |||
| ABCC1 | 0.917 | 0.321 | 0.774 | 0.000 | DOWN | 0.711 | 0.166 | 0.654 | 0.000 | DOWN | ||
| ABCC2 | 1.025 | 0.828 | 0.869 | 0.675 | 0.761 | 0.166 | 0.596 | 0.000 | DOWN | |||
| ABCC3 | 6.375 | 0.172 | 5.600 | 0.000 | UP | 4.569 | 0.170 | 3.812 | 0.174 | |||
| ABCC5 | 0.895 | 0.321 | 0.773 | 0.000 | DOWN | 0.697 | 0.166 | 0.615 | 0.000 | DOWN | ||
| ABCC6 | 1.094 | 0.321 | 0.861 | 0.675 | 0.841 | 0.499 | 1.159 | 0.000 | UP | |||
| ABCC10 | 1.006 | 0.828 | 0.752 | 0.000 | DOWN | 0.752 | 0.000 | DOWN | 0.628 | 0.000 | DOWN | |
| ABCD1 | 1.775 | 0.000 | UP | 1.664 | 0.000 | UP | 1.700 | 0.000 | UP | 1.552 | 0.000 | UP |
| ABCD2 | 2.925 | 0.000 | UP | 4.374 | 0.000 | UP | 0.827 | 0.497 | 4.267 | 0.329 | ||
| ABCD3 | 0.957 | 0.657 | 0.793 | 0.504 | 0.293 | 0.166 | 0.964 | 0.331 | ||||
| ABCD4 | 2.146 | 0.172 | 0.752 | 0.000 | DOWN | 1.822 | 0.000 | UP | 1.686 | 0.174 | ||
| ABCE1 | 1.854 | 0.000 | UP | 1.811 | 0.157 | 2.080 | 0.000 | UP | 2.234 | 0.329 | ||
| ABCF1 | 0.161 | 0.000 | DOWN | 0.182 | 0.000 | DOWN | 0.114 | 0.000 | DOWN | 0.208 | 0.000 | DOWN |
| ABCF2 | 2.053 | 0.000 | UP | 2.028 | 0.000 | UP | 1.753 | 0.000 | UP | 1.672 | 0.000 | UP |
| ABCF3 | 1.116 | 0.172 | 0.464 | 0.000 | DOWN | 0.993 | 0.669 | 0.799 | 0.000 | DOWN | ||
| ABCG1 | 1.448 | 0.172 | 0.844 | 0.000 | DOWN | 0.900 | 0.665 | 1.760 | 0.000 | UP | ||
| ABCG2 | 0.891 | 0.657 | 0.804 | 0.000 | DOWN | 0.922 | 0.830 | 0.716 | 0.000 | DOWN | ||
| ABCG4 | 1.854 | 0.000 | UP | 1.533 | 0.000 | UP | 1.513 | 0.166 | 1.583 | 0.000 | UP | |