Table 5.

Dimensional characteristics, agglomeration and encapsulation parameters of antioxidant-containing NLCs.

NLC preparation	Z-average, Dz (nm)	Polydispersity index	Agglomeratea (%)	Encapsulation efficiencyb	Loading capacityc
NLC T5-TOC	104.5 ± 32.0	0.33 ± 0.11	1.22 ± 0.02	90.96 ± 1.3	7.27 ± 0.1
NLC T10-TOC	82.8 ± 10.7	0.36 ± 0.05	1.24 ± 0.01	90.69 ± 2.8	7.25 ± 0.2
NLC C5-TOC	149.4 ± 36.9	0.22 ± 0.03	2.25 ± 0.01	95.61 ± 1.5	7.64 ± 0.2
NLC C10-TOC	132.7 ± 51.3	0.34 ± 0.05	3.17 ± 0.02	79.15 ± 2.5	6.33 ± 0.1
NLC P5-TOC	149.5 ± 30.3	0.30 ± 0.02	1.11 ± 0.01	93.58 ± 1.7	7.48 ± 0.1
NLC P10-TOC	118.5 ± 31.9	0.30 ± 0.05	1.12 ± 0.02	90.99 ± 2.2	7.27 ± 0.2
NLC S5-TOC	164.6 ± 21.7	0.29 ± 0.06	0.00 ± 0.01	88.16 ± 1.3	7.05 ± 0.1
NLC S10-TOC	106.1 ± 24.2	0.29 ± 0.07	0.00 ± 0.01	60.72 ± 2.1	4.85 ± 0.1
NLC T10-RA	98.4 ± 20.2	0.27 ± 0.12	2.52 ± 0.01	67.24 ± 0.8	0.16 ± 0.0

^aLoss of lipids (lipid phase) due to the partial coalescence of the lipid phase during the formation of the O/W emulsion. After cooling the coalesced lipid phase appeared as a small flake floating on the surface of the NLC dispersion. ^bPercentage (w/w) of drug in the whole dispersion with respect to the total amount used for the preparation. ^cPercentage (w/w) of drug within nanoparticles as compared to the amount of lipid used for the preparation. Data represent the mean ± S.D. of 6 independent experiments.