Figure 2.
(I) Top binding mode of phlorotannins phloroglucinol (blue stick), eckol (green stick), phlorofucofuroeckol-A (purple stick), and 974-A (yellow stick) for the oxy-form tyrosinase with positive controls, l-tyrosine (black stick) and luteolin (red stick) (A). Copper and peroxide ions are shown in orange and red spheres, respectively. (II) 2D diagram showing l-tyrosine (A), luteolin (B), phloroglucinol (C), eckol (D), phlorofucofuroeckol-A (E), and 974-A (F) binding pose in active site of tyrosinase.