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. 2019 Aug 14;24(16):2947. doi: 10.3390/molecules24162947

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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The Raman phenotypes of exosomes derived from eight different cell types. (a) Exo-SERS acquired from EC109, EC9706, Kyse150, MCF-7, M231, M-10A, HepG2 and L02 cells; (b) The two-dimensional scatter plot of PC1 (48.98%) and PC2 (23.49%) showed that the esophageal cancer cell-derived exosomes were absolutely distinguished from other cell derived exosomes by selecting the 600–760 cm⁻¹ region; (c) Three-dimensional scatter plot of PC1 (50.03%), PC2 (12.24%) and PC3 (8.12%) showed that the breast cell-derived exosomes were absolutely distinguished from other cell derived exosomes by selecting the 940–1100 cm⁻¹ region.