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The effect of Dinaciclib treatment on H460 cells in vitro and in vivo. a The effects of Dinaciclib (concentration: 1 nM) on the expression of CDK5 and its activated form CDK5/p35 in vitro. b The effects of Dinaciclib (concentration: 1 nM) on the expression of phosphorylated c-MYC at Ser-62 site, c-MYC and BIN1. c The effects of Dinaciclib on the BIN1/c-MYC interaction. d, e The tumor volume of nude mice bearing with H460 cells. Significant P-values marked by asterisk: *P < 0.05
