Table 2.
Cytokine mRNA expression profile of wild type (WT) mouse lung tissue with gefitinib 100 mg/kg and 200 mg/kg for 14 days. The lung tissue mRNA transcripts were quantified by real-time PCR and normalized to GAPDH. The lung tissue mRNA transcripts were quantified by real-time PCR and normalized to GAPDH. The data are represented relative to control values, as means ± SEM (n = 8). Significant values are indicated in boldface.
| Control | Gef 100 mg/kg | p | Gef 200 mg/kg | p | |
|---|---|---|---|---|---|
| Ifng | 1 | 0.89 ± 0.1 | 0.37 | 0.69 ± 0.2 | 0.086 |
| Il1b | 1 | 1.9 ± 0.1 | <0.0001 | 13.7 ± 2.3 | 0.0008 |
| Il6 | 1 | 1.1 ± 0.1 | 0.31 | 1.7 ± 0.1 | <0.0001 |
| Il10 | 1 | 1.3 ± 0.1 | 0.0093 | 1.7 ± 0.1 | 0.0005 |
| Il17a | 1 | 1.0 ± 0.1 | 0.93 | 2.6 ± 0.5 | 0.024 |
| Il21 | 1 | 1.1 ± 0.1 | 0.27 | 1.1 ± 0.1 | 0.15 |
| Il23a | 1 | 1.1 ± 0.0 | 0.086 | 1.0 ± 0.0 | 0.86 |
| Tnf | 1 | 1.4 ± 0.0 | 0.17 | 1.4 ± 0.2 | 0.093 |
| Tgfb1 | 1 | 0.93 ± 0.0 | 0.076 | 0.97 ± 0.0 | 0.34 |
| Foxp3 | 1 | 1.6 ± 0.1 | <0.0001 | 1.6 ± 0.1 | 0.0051 |
| Gata3 | 1 | 0.99 ± 0.1 | 0.97 | 0.6 ± 0.1 | 0.0015 |
| Tbet | 1 | 0.82 ± 0.1 | 0.017 | 0.5 ± 0.1 | 0.0012 |
| Gm-csf | 1 | 0.80 ± 0.1 | 0.057 | 0.8 ± 0.1 | 0.16 |
| Egfr | 1 | 1.0 ± 0.1 | 0.94 | 1.0 ± 0.2 | 0.87 |