Table 2.

Stability of analytes in spiked saliva stored in a refrigerator at 8 °C and after freeze–thaw cycles at −21 °C. The stability of the extracts was maintained in an autosampler at 15 °C. The values in the table reflect the analyte concentrations as a percentage of the amount determined on the first day of the analysis.

Analyte	−21 °C			8 °C			15 °C
	15	150	750	15	150	750	15	150	750
Aripiprazole	104.56	105.50	100.56	102.06	104.37	98.19	100.77	105.81	107.05
Dehydroaripiprazole	96.62	104.47	103.63	102.22	100.81	98.41	94.48	98.94	94.15
Carbamazepine	97.46	100.24	98.43	98.67	93.01	97.17	105.11	102.30	101.63
Carbamazepine-10,11 epoxide	97.85	106.34	104.95	94.37	102.88	106.16	83.44	84.15	80.95
Clozapine	103.71	102.87	90.42	102.45	95.16	107.22	87.59	91.13	103.52
N-desmethylclozapine	104.04	107.16	88.85	100.04	93.44	86.48	102.61	104.16	110.63
Olanzapine	104.41	95.73	94.50	92.28	108.57	84.63	98.22	80.95	81.17
N-demethyl olanzapine	98.62	99.03	95.98	104.78	102.72	93.67	76.43	77.71	78.25
Quetiapine	94.10	95.38	89.75	95.55	94.05	103.32	102.39	109.49	112.65
Norquetiapine	104.79	110.72	94.04	108.10	112.46	105.59	106.99	106.27	109.07
Risperidone	100.32	112.60	90.87	98.71	103.92	108.15	101.45	106.90	103.88
9-OH-risperidone	103.89	112.47	90.32	106.80	102.79	107.64	105.16	99.07	98.29