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MEK1 inhibitory activities of compounds 6a and 10a-j. The results are expressed as mean value ± SD.
| Compound | IC50 value (μM) |
|---|---|
| 6a | 13.21 ± 0.73 |
| 10a | 6.36 ± 0.51 |
| 10b | >20 |
| 10c | >20 |
| 10d | >20 |
| 10e | 1.28 ± 0.06 |
| 10f | 0.23 ± 0.03 |
| 10g | 0.11 ± 0.02 |
| 10h | 1.63 ± 0.12 |
| 10i | >20 |
| 10j | 5.62 ± 0.48 |
| 10k | >20 |
| AZD6244 | 0.029 ± 0.003 |
