Table 1.

Selected client proteins of HSP90 related with tumor growth and survival

Class	Client protein of HSP90	Function	References
Receptor tyrosine kinase	Her2/ErbB2	Promotes cell proliferation and inhibits apoptosis	Moasser, 2007
	EGFR mutant	Promotes cell proliferation via activation of MAPK, AKT and JNK pathway	Voldborg et al., 1997
	FLT3	Regulates cell survival, proliferation and differentiation	Grafone et al., 2012
	VEGFR	Promotes vasculogenesis and angiogenesis	Kliche and Waltenberger, 2001
Signaling molecule and Kinase	Akt	Plays a role in apoptosis, cell proliferation, transcription and cell migration	Yoeli-Lerner and Toker, 2006
	mTOR	Regulates cell proliferation, motility and survival	Guertin and Sabatini, 2007
	p38	Regulates cell proliferation, apoptosis and motility	Koul et al., 2013
	v-Src	Promotes formation of cancer, cell movement and proliferation	Irby and Yeatman, 2000
	Raf-1 b-Raf	Activates cell growth signaling, such as MEK1/2 and ERK1/2	Leicht et al., 2007
	JAK2	Promotes cell proliferation and motility	Xu et al., 2017
	Bcr-Abl	Promotes cell proliferation and reduces apoptosis	Quintas-Cardama and Cortes, 2009
Transcription factor	Twist1	Promotes cancer metastasis and reduces apoptosis	Puisieux et al., 2006
	Hif-1α	Induce cell proliferation and angiogenesis	Tiburcio et al., 2014
	NF-κB	Keeps cell proliferation and protects from apoptosis	Xia et al., 2014
	p53 mutant	Transactivates growth-promoting and oncogenic genes	Ozaki and Nakagawara, 2011
Others	Cyclin D1	Controls cell cycle	Qie and Diehl, 2016
	VDUP-1	Inhibits cell growth and metastasis and contributes to apoptosis	Kaimul et al., 2007
	MUC1	Prevents cell death and promotes proliferation and invasion	Nath and Mukherjee, 2014
	MMP2/9	Plays a role in invasion and angiogenesis via breakdown of extracellular matrix	Gialeli et al., 2011
	Survivin	Inhibits apoptosis and regulates mitosis	Mita et al., 2008
	Vimentin	Increases migration and invasive capacity	Satelli and Li, 2011