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. 2019 Aug 17;20(16):4014. doi: 10.3390/ijms20164014

Figure 6.

Figure 6

Pharmacophores exhibited by molecules targeting TASK channels. (A) Pharmacophore shared by molecules, such as A1899, targeting TASK-1 and Kv1.5 channels [35]. (B) Pharmacophore found and used in this work to discover new TASK blockers shared by A1899 and molecules from THPP series such as PK-THPP (no. 23), 17e and 12f. (C) Pharmacophore described for the molecules of THPP series [20]. In all pharmacophores, R (aromatic ring, orange circle), A (H-Bond acceptor group, red dot) and the green dots represent hydrophobic groups in C.