Table 2.

TASK-3 modulators with different chemical characteristics were used for the generation of the energy-optimized pharmacophore.

Blocker	ID	TASK-3 IC50 (μM)	Reference
	12f	0.074	[25]
	17e	0.57	[25]
	23	0.035	[6,25]
	A1899	1.6	[6,30]
	Dihydro-Beta-erythroidine	73.8	[32]
	Doxapram	23.1	[6]
	GW2974	50.1	[32]
	L-703,606	45.5	[32]
	Loratadine	63.4	[32]
	Mevastatin	159	[32]
	Mibefradil	24.6	[32]
	Octoclothepin	73.8	[32]