Table 1.
Successfully treated cases of ‘cepacia syndrome’ in patients with cystic fibrosis
| Author | Age (years) | Gender | Pre-existing comorbidity | Pre-existing immunosuppression | Organism | Systemic antibiotics | Nebulised antibiotics | Additional treatment |
| Grimwood et al 13 | 10 | F | – | – | Burkholderia cenocepacia | Ceftazidime, trimethoprim-sulfamethoxazole, tobramycin | Tobramycin | Recombinant human DNase |
| Kazachkov et al 16 | 11 | F | – | – | B. cepacia | Ceftazidime, meropenem, chloramphenicol, trimethoprim-sulfamethoxazole | – | Methylprednisolone |
| Weidmann et al 15 | 31 | F | En-bloc liver–pancreas transplant | Mycophenolate mofetil, tacrolimus | B. cenocepacia | Meropenem, trimethorpim-sulfamethoxazole, temocillin | Meropenem Tobramycin |
– |
| Nash et al 17 | 24 | M | Bilateral lung transplant | Tacrolimus, azathioprine (temporarily withheld during episode of sepsis), prednisone | B. cenocepacia | Ticarcillin-clavulanate, meropenem, amikacin, colistin | Amikacin Colistin | – |
| 24 and 30 (same patient with two different episodes) | F | Bilateral lung transplant | Ciclosporin, azathioprine, prednisone | B. cenocepacia | 1st episode—Ceftazidime, tobramycin, chloramphenicol (oral) 2nd episode —Meropenem, ciprofloxacin (oral), azithromycin (oral) and doxycycline (oral) |
Tobramycin | Surgical debridement | |
| Gilchrist et al 14 | 38 | M | – | – | B. cenocepacia | Tobramycin, meropenem, trimethoprim-sulfamethoxazole, choramphenicol | – | Oral prednisolone, ciclosporin |