. 2019 Aug 21;2019:8262849. doi: 10.1155/2019/8262849

Table 1.

Lung morphometry.

Groups		Normal alveoli (%)	Alveolar collapse (%)	Neutrophils (%)	Interstitial edema	Collagen fibers (%)
Cp		95.4 ± 1.9	4.6 ± 1.9	2.5 ± 0.8	0.17 ± 0.04	36.2 ± 2.7
ARDSp	SAL	76.6 ± 3.0^∗	23.4 ± 3.0^∗	14.8 ± 4.0^∗	0.49 ± 0.10^∗	47.7 ± 3.5^∗
	MSC	93.2±2.1^∗∗	6.8±2.1^∗∗	3.0±0.4^∗∗	0.31±0.04^∗∗	38.7±3.1^∗∗
	MSC serum	92.4±2.4^∗∗	7.6±2.4^∗∗	3.4±0.5^∗∗	0.28±0.04^∗∗	37.7±5.6^∗∗
	EV	89.8±1.0^∗,∗∗^,#	10.2±1.0^∗,∗∗^,#	6.4±0.3^∗,∗∗^,#	0.38 ± 0.07^∗	39.0 ± 6.2
	EV serum	86.7±2.3^∗,∗∗^,†	13.3±2.3^∗,∗∗^,†	6.5±0.7^∗,∗∗^,†	0.45 ± 0.15^∗	41.3 ± 4.6

Cexp		96.4 ± 1.2	3.6 ± 1.2	2.7 ± 1.3	0.16 ± 0.07	34.3 ± 6.7
ARDSexp	SAL	73.4 ± 5.4^∗	26.6 ± 5.4^∗	21.3 ± 2.3^∗	0.44 ± 0.08^∗	43.9 ± 3.4^∗
	MSC	92.0±2.7^∗∗	8.0±2.7^∗∗	5.1±0.5^∗∗	0.25±0.07^∗∗	37.5±2.3^∗∗
	MSC serum	93.3±1.9^∗∗	6.7±1.9^∗∗	4.3±1.1^∗∗	0.29±0.06^∗∗	37.8±1.8^∗∗
	EV	88.7±1.6^∗,∗∗^,#	11.3±1.6^∗,∗∗^,#	7.8±0.4^∗,∗∗^,#	0.30 ± 0.07^∗	40.8 ± 1.6
	EV serum	87.6±2.9^∗,∗∗^,†	12.4±2.9^∗,∗∗^,†	8.8±1.7^∗,∗∗^,†	0.39 ± 0.09^∗	42.9 ± 6.1

Fraction area of normal and collapsed alveoli, neutrophil cell count, interstitial edema, and collagen fiber content in the alveolar septa. All values were computed in 10 random, noncoincident fields of view per mouse. Values were expressed as mean ± standard deviation of six animals per group. ARDS was induced by administration of Escherichia coli lipopolysaccharide intratracheally (ARDSp) or intraperitoneally (ARDSexp). Control mice (C) received saline solution intratracheally (Cp) or intraperitoneally (Cexp). After 24 h, ARDSp and ARDSexp animals were further randomized to receive saline (50 μL, SAL), bone marrow-derived MSCs (10⁵, 50 μL), or EVs (10⁵, 50 μL), stimulated (MSC serum, EV serum) or not with serum (MSCs, EVs) obtained from ARDSp or ARDSexp animals. ^∗Significantly different from the corresponding C group. ^∗∗Significantly different from the corresponding ARDS group. ^#Significantly different from MSC. ^†Significantly different from MSC serum (p < 0.05).