Table 6.
Association of clinical status with rs13281615 in CASC8 among HCC patients who do not smoke.
| Genotypic Frequencies | ||||
|---|---|---|---|---|
| Variable | AA (%) (n = 70) | AG+GG (%) (n = 169) | OR (95% CI) | p Value |
| Clinical Stage | ||||
| Stage I/II | 54 (77.1%) | 116 (68.6%) | 1.000 (reference) | |
| Stage III/IV | 16 (22.9%) | 53 (31.4%) | 1.542 (0.809–2.941) | p = 0.189 |
| Tumor size | ||||
| ≤T2 | 55 (78.6%) | 120 (71%) | 1.000 (reference) | |
| >T2 | 15 (21.4%) | 49 (29%) | 1.497 (0.773–2.898) | p = 0.231 |
| Lymph node metastasis | ||||
| Negative | 68 (97.1%) | 164 (97%) | 1.000 (reference) | |
| Positive | 2 (2.9%) | 5 (3%) | 1.037 (0.196–5.474) | p = 0.966 |
| Distant metastasis | ||||
| Negative | 68 (97.1%) | 159 (94.1%) | 1.000 (reference) | |
| Positive | 2 (2.9%) | 10 (5.9%) | 2.138 (0.456–10.02) | p = 0.335 |
| Vascular invasion | ||||
| No | 61 (87.1%) | 140 (82.8%) | 1.000 (reference) | |
| Yes | 9 (12.9%) | 29 (17.2%) | 1.404 (0.627–3.144) | p = 0.409 |
| Child-Pugh grade | ||||
| A | 51 (72.9%) | 143 (84.6%) | 1.000 (reference) | |
| B or C | 19 (27.1%) | 26 (15.4%) | 0.488 (0.249–0.956) | p = 0.037 * |
| HBsAg | ||||
| Negative | 45 (64.3%) | 92 (54.4%) | 1.000 (reference) | |
| Positive | 25 (35.7%) | 77 (45.6%) | 1.507 (0.848–2.677) | p = 0.162 |
| Anti-HCV | ||||
| Negative | 35 (50%) | 97 (57.4%) | 1.000 (reference) | |
| Positive | 35 (50%) | 72 (42.6%) | 0.742 (0.424–1.298) | p = 0.296 |
| Liver cirrhosis | ||||
| Negative | 10 (14.3%) | 32 (18.9%) | 1.000 (reference) | |
| Positive | 60 (85.7%) | 137 (81.1%) | 0.714 (0.330–1.544) | p = 0.392 |
> T2: multiple tumors > 5 cm or tumor bearing a major branch of the portal or hepatic vein(s). * p value < 0.05.