Figure 4.

Deletion of the Grx2 gene does not alter the rate of H₂O₂ production by muscle mitochondria isolated from female mice. Rates of production by mitochondria energized with pyruvate (A), α-ketoglutarate (B), or succinate (C) at a concentration range of 10–10,000 µM. (D). Comparison of the rates of ROS production in mitochondria isolated from WT, GRX2+/−, and GRX2−/− mice oxidizing 50 µM pyruvate, α-ketoglutarate, or succinate. n = 4, mean ± SEM, 2-way ANOVA with a post-hoc Tukey’s test. ###: p ≤ 0.001