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. 2019 Aug 19;24(16):3000. doi: 10.3390/molecules24163000

Figure 4.

Figure 4

Inhibitory effect of APINACA on the metabolic activities of six uridine 5′-diphospho-glucuronosyltransferase (UGT) enzymes in pooled human liver microsomes with (◯) and without (⬤) a 30-min preincubation in the presence of uridine 5′-diphosphoglucuronoic acid (UDPGA) at 37 °C. The cocktail UGT substrate concentrations were as follows: 0.5 µM SN-38 for UGT1A1, 2 µM chenodeoxycholic acid for UGT1A3, 0.5 µM trifluoperazine for UGT1A4, 1 µM N-acetylserotonin for UGT1A6, 0.2 µM mycophenolic acid for UGT1A9, and 1 µM naloxone for UGT2B7. The data are the means ± SD (n = 3).