Table 4.
Seventeen KEEG pathways enriched by 49 potential targets of licorice with p-value less than 0.01.
| ID | Pathway Name | Common Genes | Nr | %Associated Genes | p-Value |
|---|---|---|---|---|---|
| 1 | Steroid hormone biosynthesis | CYP19A1, CYP1A1, CYP1A2, HSD11B1, HSD11B2, HSD17B1, HSD17B2 | 7 | 12.07 | 9.17 × 10−9 |
| 2 | Tyrosine metabolism | ALDH1A3, MAOA, MAOB, MIF, TYR | 5 | 14.29 | 6.05 × 10−7 |
| 3 | Phenylalanine metabolism | ALDH1A3, MAOA, MAOB, MIF | 4 | 23.53 | 1.08 × 10−6 |
| 4 | Ovarian steroidogenesis | ALOX5, CYP19A1, CYP1A1, HSD17B1, HSD17B2 | 5 | 10.00 | 3.74 × 10−6 |
| 5 | Arginine and proline metabolism | MAOA, MAOB, NOS1, NOS2, NOS3 | 5 | 10.00 | 3.74 × 10−6 |
| 6 | Arachidonic acid metabolism | ALOX12B, ALOX15, ALOX15B, ALOX5, CBR3 | 5 | 8.06 | 1.10 × 10−5 |
| 7 | Serotonergic synapse | ALOX12B, ALOX15, ALOX15B, ALOX5, MAOA, MAOB | 6 | 5.31 | 1.52 × 10−5 |
| 8 | Metabolism of xenobiotics by cytochrome P450 | ALDH1A3, CBR3, CYP1A1, CYP1A2, HSD11B1 | 5 | 6.76 | 2.61 × 10−5 |
| 9 | Tryptophan metabolism | CYP1A1, CYP1A2, MAOA, MAOB | 4 | 10.00 | 3.82 × 10−5 |
| 10 | Arginine biosynthesis | NOS1, NOS2, NOS3 | 3 | 14.29 | 1.32 × 10−4 |
| 11 | Histidine metabolism | ALDH1A3, MAOA, MAOB | 3 | 12.50 | 1.99 × 10−4 |
| 12 | Retinol metabolism | ALDH1A1, CYP1A1, CYP1A2, RDH8 | 4 | 6.15 | 2.59 × 10−4 |
| 13 | p53 signaling pathway | CCNB3, CDK1, CDK2, CDK6 | 4 | 5.80 | 3.26×10−4 |
| 14 | Drug metabolism | ALDH1A3, CYP1A2, MAOA, MAOB | 4 | 5.71 | 3.45 × 10−4 |
| 15 | Chemical carcinogenesis | ALDH1A3, CYP1A1, CYP1A2, HSD11B1 | 4 | 4.88 | 6.31 × 10−4 |
| 16 | ABC transporters | ABCB1, ABCB4, ABCG2 | 3 | 6.67 | 1.30 × 10−3 |
| 17 | Bile secretion | ABCB1, ABCB4, ABCG2 | 3 | 4.23 | 4.80 × 10−3 |