Fig. 2.

Signature prediction on a simulated mutational catalogue. The catalogue is sampled from set1 signatures (7, 13, 21, 24 and 27), each occurring with a probability of 20% (a), and from set2 (3, 5, 8, 16 and 25), with the same 20% occurring probability (b). In both case, the mutation catalogue consists of 1000 mutations and was bootstrapped 1000 times. The signature contribution was predicted with quadratic programming, for each re-sample the distribution is shown. The stars mark the prediction for the original profile