Table 1.
Summary of the ncRNA-mediated regulations for the HNSCC metabolism.
| Cancer Type | ncRNA | Regulating Target/Role | Molecular Alterations | Reference |
|---|---|---|---|---|
| Bladder cancer | LncUCA1 | glucose metabolism | hexokinase 2 (HK2)↑, mTOR-STAT3↑ | [151] |
| Hepatocellular carcinoma | LncHULC | lipid metabolism | ACSL1↑ | [152] |
| Colon cancer | LncRNA LINC01234 | amino acid metabolism | miR-642a↓ | [153] |
| Head and neck cancer | LncCAF (FLJ22447) | oncogenic | IL-33↑ | [155] |
| Head and neck cancer | LncZFAS1 | tumor suppressive | EGFR↓, PD-L1↓ | [156] |
| Head and neck cancer | LncHIFCAR (MIR31HG) | glucose metabolism | HIF-1↑ | [157] |
| Head and neck cancer | ncHAS2-AS1 | hypoxia | [158] | |
| Larynx carcinoma | LncPCAT19 | mitochondria | miR-182↑ | [156] |
| Head and neck cancer | miR-34a | tumor suppressive | VEGF↓, AXL↓ | [160,161] |
| Acute myeloid leukemia | miR-34a | PD-L1↓ | [162] | |
| Pancreatic ductal adenocarcinoma | miR-34a | [163] | ||
| Oropharyngeal squamous cell carcinoma | miR-210 | ISCU↓ | [168] | |
| Head and neck cancer | miR-340 | glucose metabolism | GLUT1↑ | [169] |
| Head and neck cancer | miR-21, LncRNAs HOXA11-AS, LINC00964 and MALAT-1 | plasma biomarker | [173] | |
| Head and neck cancer | miR-146a | plasma biomarker | [174] | |
| Head and neck cancer | MALAT-1, HOTAIR, NEAT-1, HULC, MEG-3 and UCA1 | oncogenic | [175] | |
| Head and neck cancer | miR-125a and miR-200a | salivary marker | [176] | |
| Esophageal cancer | miR-21 | salivary marker | [177,178] | |
| Head and neck cancer | miR-31 | plasma and salivary biomarker | [179,180] |