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The cytostatic activities of C-5 aryl-, alkenyl-, and alkynyl-substituted uracil derivatives of ASA.
| Comp. | IC50 (μM) | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| L1210 | Molt4/C8 | CEM/0 | HeLa | MCF-7 | MiaPaCa-2 | Hep-2 | SW 620 | WI 38 | |
| 45a, R5 = propynyl | 0.47 | 0.78 | 0.77 | 0.2 | 0.2 | 0.5 | 0.7 | 0.3 | 0.2 |
| 45b, R5 = furyl | 6.8 | 6.6 | 7.0 | 2 | 2 | 1.6 | 2.2 | 2.4 | 1.8 |
| 45c, R5 = vinyl | 7.2 | 7.6 | 7.2 | 14.5 | 3.8 | 22 | 14.2 | 15.6 | 14.3 |
| 45d, R5 = ethynyl | 6.8 | 7.2 | 4.6 | 3.2 | 2.9 | 8.7 | 4.6 | 5 | 1.5 |
| 45e, R5 = isopentenyl | 8.2 | 8.3 | 7.7 | 2 | 4 | 5 | 2.6 | 4 | 2 |
| 46a, R5 = ethynyl-Ph | 8.1 | 8.2 | 7.6 | 2 | 1 | 3 | 3 | 4 | 1 |
