Table 19.
The cytostatic activities of C-5 substituted pyrimidine and 6-alkylfuro[2–3-d]pyrimidine-4,5-didehydro-l-ASA derivatives.
| Comp. | IC50 (μM) | |||||||
|---|---|---|---|---|---|---|---|---|
| L1210/0 | Molt4/C8 | CEM/0 | HeLa | MiaPaCa-2 | SW 620 | MCF-7 | H-460 | |
| 47a, R = hexyl | 6.8 | 3.0 | 2.0 | 12 | 3 | 4 | 4 | 2.4 |
| 47b, R = 4-Br-Ph | 10 | 15 | 7.6 | 8 | 13 | 7 | 21 | 11 |
| 47c, R = 4-CH3-Ph | 8.7 | 37 | 9.6 | 14 | 21 | 18 | 19 | 23 |
| 47d, R = 4-butyl-Ph | 8.2 | 9.3 | 8.3 | 4 | 16 | 7 | 17 | 12 |
| 47e, R = 4-pentyl-Ph | 8.0 | 6.9 | 6.6 | 3 | 10 | 6 | 9 | NT a |
| 48a, R = butyl | 4.5 | 9.0 | 7.7 | 17 | 15 | 16 | 16 | 16 |
| 48b, R = 4-Br-Ph | 9.5 | 9.6 | 8.3 | 20 | 14 | 20 | 13 | 16 |
a NT = not tested.