Table 2.

Correlation of microRNA expression and clinical parameters in chronic Chagas disease subjects.

miRNAs	Cardiac Dysfunction	Age	NYHA (II-IV)	%Fibrosis	EF (CMR)	Strain (LV)	Ventricular Arrhythmia	SV Arrhythmia	HR Variability
miR-19a-3p	r = 0.47	r = 0.20	r = 0.47	r = 0.41	r = −0.40	r = −0.36	r = 0.15	r = 0.09	r = −0.11
	p = 0.003 **	p = 0.22	p = 0.003 **	p = 0.01 *	p = 0.01 *	p = 0.02 *	p = 0.37	p = 0.59	p = 0.54
miR-21-5p	r = 0.42	r = 0.06	r = 0.42	r = 0.38	r = −0.40	r = −0.34	r = 0.16	r = 0.02	r = −0.21
	p = 0.008 **	p = 0.70	p = 0.008 **	p = 0.03 *	p = 0.01 *	p = 0.04 *	p = 0.32	p = 0.89	p = 0.24
miR-29b-3p	r = 0.47	r = 0.04	r = 0.47	r = 0.36	r = −0.34	r = −0.32	r = 0.24	r = 0.27	r = −0.34
	p = 0.02 *	p = 0.79	p = 0.02 *	p = 0.03 *	p = 0.03 *	p = 0.05	p = 0.13	p = 0.09	p = 0.05
miR-199b-3p	r = 0.24	r = −0.27	r = 0.24	r = 0.01	r = −0.28	r = −0.18	r = 0.03	r = −0.07	r = −0.11
	p = 0.16	p = 0.12	p = 0.16	p = 0.96	p = 0.10	p = 0.31	p = 0.85	p = 0.66	p = 0.54

n = 38 subjects (indeterminate form and chronic Chagas cardiomyopathy). EF = ejection fraction. CMR = cardiovascular magnetic resonance. LV = left ventricular. SV = supra ventricular, HR= heart rate. Spearman, * p < 0.05; ** p < 0.01.