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. 2019 Aug 15;20(16):3969. doi: 10.3390/ijms20163969

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(a) Statistical analysis of mRNA level assessed by realtime-PCR showed that that interventional treatment with antisense oligomer (ASO); a novel specific TXNIP inhibitor; blunted the increase of TXNIP mRNA 14-days post IR-injury. (* p < 0.05 two-way ANOVA showed significant interaction of IR and treatment, N = 3–4) (b,c) Western blot analysis showed that interventional treatment with TXNIP-ASO blunted the increase of the ER-stress marker, CHOP and the apoptotic marker Phosphorylated-JNK expression after retinal IR. (* p < 0.05 vs. sham, n = 3–4).