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. 2019 Jul 30;8(8):256. doi: 10.3390/antiox8080256

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of DM on CDDP-induced nephrotoxicity in rats. (A) Serum biochemical parameters were measured in CDDP-treated rats. Values are the mean ± SD of six rats per group. Statistical analyses were performed using one-way ANOVA followed by Tukey’s HSD post hoc test for multiple comparisons. ^## p < 0.01 compared to the control group; ** p < 0.01 compared to the CDDP-treated group. (B) H&E staining of representative kidney tissues from all experimental groups. Black arrows indicate renal tissue necrosis and infiltration in the proximal tubules. Magnification ×100.