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. 2019 Jul 30;8(8):256. doi: 10.3390/antiox8080256

Figure 9.

Figure 9

Protective effect of DM on CDDP-induced nephrotoxicity in tumor xenograft mice transfected with HCT-116 cells. (A) Kidney weight, nephrotoxicity biomarkers, and inflammatory cytokine levels were measured in the serum of tumor-bearing mice treated with CDDP. Values are the mean ± SD of six mice per group. Statistical analyses were performed using one-way ANOVA followed by Tukey’s HSD post hoc test for multiple comparisons. ## p < 0.05 and ## p < 0.01 compared to the control group; * p < 0.05 and ** p < 0.01 compared to the CDDP-treated group. (B) Representative histology of H&E-stained kidney sections in the experimental groups of a tumor xenograft mouse model. At 31 days, CDDP-induced acute kidney injury (AKI) mice presented an enlarged cortex with glomerular sclerosis (arrowheads). The cortex from CDDP-treated mice exhibited a normal-sized renal cortex and a lower incidence of tubular and medulla injury and displayed a normal histological structure of thin tubules and collecting ducts. Images are representative of three animals per experimental group (magnification ×100, bar = 100 μm).