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. 2019 Jul 30;8(8):256. doi: 10.3390/antiox8080256

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Protective effect of DM on nephrotoxicity biomarkers in CDDP-induced nephrotoxicity in tumor xenograft mice transfected with HCT-116 cells. (A) Nephrotoxicity biomarkers were measured in the kidney of mice. Representative Western blots of NGAL, KIM-1, and SBP1 from triplicate experiments are shown. (B) Densitometric analysis showed the expression of SBP1, KIM-1, and NGAL in the kidney of mice with CDDP-induced nephrotoxicity. ** p < 0.01 compared to the CDDP-treated group. (C) Representative immunohistochemical staining of KIM-1, NGAL, and SBP1 in the kidney of mice with CDDP-induced nephrotoxicity. Original magnification ×100, scale bar: 50 μm.