Table 2.
Anti-inflammatory (EC50, μg/mL) and cytotoxicity properties (GI50, μg/mL) of S. apiana and S. farinacea var. Victoria Blue decoctions.
| Effect | S. apiana | S. farinacea var. Victoria Blue | Standard |
|---|---|---|---|
| Anti-inflammatory activity | Dexamethasone | ||
| NO● production | 49.9 ± 2.5 a | 80.8 ± 0.4 b | 16.0 ± 1.0 c |
| Cytotoxicity to tumor cell lines | Ellipticine | ||
| HepG2 (hepatocellular carcinoma) | 40.9 ± 3.3 a | 87.4 ± 5.4 b | 1.0 ± 0.2 c |
| HeLa (cervical carcinoma) | 57.3 ± 5.1 a | 77.8 ± 3.5 b | 2.0 ± 0.1 c |
| MCF-7 (breast carcinoma) | 60.2 ± 4.2 a | 59.8 ± 0.1 a | 1.0 ± 0.04 b |
| NCI-H460 (non-small cell lung cancer) | 245.7 ± 6.3 a | 279.5 ± 10.1 b | 1.0 ± 0.1 c |
| Cytotoxicity to non-tumor cells | |||
| PLP2 growth inhibition | 361.7 ± 5.3 a | 335.4 ± 8.0 b | 3.0 ± 1.0 c |
Results of anti-inflammatory activity are expressed in EC50 values: sample concentration providing 50% of inhibition of nitric oxide (NO●) production. Cytotoxicity results are expressed in GI50 values (half maximal inhibition concentration) corresponding to the sample concentration achieving 50% of growth inhibition in human tumor cell lines or in liver primary culture PLP2. Means followed by the same letters in rows do not differ according to Tukey’s test (p < 0.05).