Skip to main content
. 2019 Aug 19;2019:8781690. doi: 10.1155/2019/8781690

Figure 2.

Figure 2

BA induces breast cancer cell DNA damage and inhibits EMT and MMPs. (a) TUNEL assay showed that BA induced MDA-MB-231 and BT-549 apoptosis (the scale bars indicate 50 μm). (b) BA broke double-strand DNA in MDA-MB-231 and BT-549 cells, as represented by H2AX activation (the scale bars indicate 20 μm). (c) BA reversed EMT in breast cancer cells, represented by a dose-dependent decrease in N-cadherin and vimentin and an increase in E-cadherin. MMP-2 and MMP-9 were also downregulated by BA treatment. (d) Gelatin zymography assay indicated that BA downregulated MMP-2 and MMP-9 secreted by breast cancer cells.