Table 1.
In situ visualization of tumor-associated DCs.
| Histology | Biomarkers | DC Subset | Localization | Maturation State | Reference |
|---|---|---|---|---|---|
| Breast cancer | CD1a, CD207, CD83 | DC, LC | Intratumoral | Immature | [116] |
| DC-LAMP, CD11c | cDC | Peritumoral | Mature | ||
| CD1a | LC | Intratumoral | NA | [117] | |
| CD1a | LC | Intratumoral | NA | [118] | |
| CD1a, CMRF-44, CMFR-56, CD83 | cDC, LC | Intra and peritumoral | Immature | [119] | |
| CD1a, CD83 | DC, LC | Intratumoral | Mature | [120] | |
| CD1a | LC | Intratumoral | NA | [121] | |
| CD1a, CD207 | LC | Intratumoral | Immature | [122] | |
| DC-LAMP | DC | Peritumoral | Mature | ||
| CD123 | pDC | Intratumoral | Immature | ||
| BDCA2 | pDC | Intratumoral | NA | [44] | |
| DC-LAMP | DC | Intratumoral | Mature | [123] | |
| Colorectal cancer | CD1a | LC | Intratumoral | Immature | [124] |
| CD83 | cDC | Peritumoral | Mature | ||
| CD1a | LC | Peritumoral | Immature | [125] | |
| DC-LAMP | DC | Intratumoral | Mature | ||
| CD1a, CD207, CD123, DC-LAMP | DC, LC, pDC | Intratumoral | NA or mature | [115] | |
| Lung cancer | CD11c, BDCA2, CD83, Lin- | cDC, pDC | Intratumoral | Immature | [126] |
| DC-LAMP | DC | Tertiary Lymphoid Structure | Mature | [127] | |
| Melanoma | CD1a, CD207, DC-SIGN, CD206 | cDC, LC | NA | NA | [128] |
| BDCA2 | pDC | NA | NA | ||
| CD207, CD1a | LC | NA | NA | [129] | |
| CD1a, DC-LAMP | DC, LC | Intratumoral | Immature | [130] | |
| CD1a, DC-LAMP | DC, LC | Peritumoral | Mature | ||
| CD11c, BDCA3 | cDC1 | NA | NA | [81] | |
| BDCA1 | cDC2 | NA | NA | ||
| Ovarian cancer | BDCA2 | pDC | NA | NA | [131] |
| Kidney cancer | CD80, CD83, CD86, HLA-DR, CMH-I, CD54 | cDC | NA | Mature | [132] |
| CD1a, CD80, CD86, CD83, CMRF-44 | cDC, LC | Intratumoral | Immature | [133] | |
| CD1a, CD40, CD80, CD83, CD86, HLA-DR | cDC, LC | Intratumoral | Mature and Immature | [134] | |
| CD1a | LC | Intratumoral | Immature | [135] | |
| CD83 | DC | Peritumoral | Mature | ||
| Head and Neck cancer | CD1a, HLA-DR | LC | Intratumoral | Mature | [136] |
| LC | Peritumoral | Immature | |||
| CD1a | LC | Intratumoral | Immature | [137] | |
| LC | Peritumoral | Immature | |||
| BDCA2, CD123, HLA-DR | pDC | Intratumoral | Immature | [138] | |
| CD1a | LC | Intratumoral | Immature | [139] | |
| DC-LAMP | DC | Peritumoral | Mature | ||
| Bladder cancer | CD83 | DC | Intratumoral | Mature | [140] |
| Gastric cancer | DC-LAMP | DC | Intra and peritumoral | Mature | [141] |
DC: Dendritic Cells; LC: langerhans cells; cDC: conventional dendritic cells; cDC1: conventional dendritic cell type 1; cDC2: conventional dendritic cell type 2; pDC: plasmacytoid dendritic cells; NA: not available