Table 3.
PG2-induced alteration in patients’ inflammatory cytokine profile.
| Cytokines | Baseline | Visit 1 | Visit 2 | Visit 3 | p-value for change |
|---|---|---|---|---|---|
| IL-1β | 155.5 ± 44.3 | 131.8 ± 40.4 | 119.02 ± 2.15 | 104.4 ± 3.8 | 0.014 |
| IL-4 | 143.1 ± 28.6 | 132.4 ± 39.9 | 120.54 ± 4.3 | 102.8 ± 2.7 | 0.04 |
| IL-6 | 147.4 ± 28 | 133.1 ± 39.4 | 122.15 ± 1.16 | 103.6 ± 3.2 | 0.012 |
| MCP-1 | 143.5 ± 28.3 | 131.2 ± 40.9 | 121.63 ± 0.42 | 103.6 ± 3.3 | 0.017 |
| IL-10 | 152.6 ± 45.3 | 132.4 ± 39.9 | 122.78 ± 2.06 | 103.6 ± 3.3 | 0.019 |
| IL-12 | 151.1 ± 46.4 | 133 ± 39.5 | 122.62 ± 1.82 | 104.1 ± 2.8 | 0.03 |
| IL-13 | 154.3 ± 46.1 | 132.4 ± 39.9 | 120.00 ± 3.54 | 102.8 ± 2.8 | 0.025 |
| IL-17 | 153.4 ± 44.9 | 133.7 ± 38.9 | 120.23 ± 3.87 | 102.9 ± 2.7 | 0.018 |
| GM-CSF | 160.3 ± 45.8 | 133 ± 39.5 | 119.54 ± 2.88 | 105.2 ± 3 | 0.014 |
| VEGF | 153.7 ± 44.8 | 133.6 ± 39 | 120.23 ± 3.87 | 105.6 ± 3.6 | 0.023 |
| TGF-β1 | 153.3 ± 44.9 | 132.9 ± 39.5 | 120.17 ± 3.78 | 105.1 ± 3.2 | 0.024 |
| IFN-γ | 151.3 ± 46 | 133 ± 39.5 | 120.17 ± 3.77 | 104.7 ± 2.7 | 0.031 |
IL: interleukin; MCP-1: Monocyte chemoattractant protein-1; GM-CSF: Granulocyte-macrophage colony-stimulating factor; VEGF: Vascular endothelial growth factor; TGF-β1: Transforming growth factor beta 1; IFN-γ: Interferon gamma.