Table 2.
The metabolites and lipids constituting the top 20 VIP’s that predict class separation on the day of transplant between those patients who eventually went on to develop GVHD as opposed to those who did not develop GVHD following SCT. Patients that went onto develop GVHD had decreased 2-aminobutyric acid, hexose, unsaturated fatty acids, and plasmenyl-ethanolamine PE (p-34:1) or PE (o-34:2), along with elevated monoacylglycerols and diacylglycerols, lysophosphocholines, phosphocholines. and phosphoethanolamines. GVHD’ patients (YES) and non-GVHD (NO) are represented by dark grey (high) or light grey (low), respectively.
| Class | Predictors | VIP | GVHD | |
|---|---|---|---|---|
| NO | YES | |||
| Alpha-amino acid | 2-aminobutyric acid | 1.80 | ||
| Monosaccharide | Hexose | 2.67 | ||
| Monoacylglycerol | 1-monoolein | 2.11 | ||
| 1-monopalmitin | 2.54 | |||
| Diacylglycerol | DG 38:5 | 1.97 | ||
| DG 38:6 | 1.91 | |||
| Fatty acid | FA 14:1 | 1.90 | ||
| FA 16:1 | 2.08 | |||
| FA 18:1 | 1.92 | |||
| FA 19:1 | 2.09 | |||
| FA 20:1 | 2.01 | |||
| FA 20:3 | 2.07 | |||
| Lysophosphatidylcholine | LPC 14:0 | 2.79 | ||
| LPC 20:0 | 2.46 | |||
| Phosphatidylcholine | PC 28:0 | 2.29 | ||
| PC 14:0/16:1 | 1.95 | |||
| PC 16:0/18:3 | 1.95 | |||
| Phosphatidylethanolamine | PE 16:0/18:1 | 2.02 | ||
| PE 18:0/22:5 | 2.23 | |||
| Plasmenyl-ethanolamine | PE (p-34:1) or PE (o-34:2) | 1.75 | ||