Table 1.

Contribution of some historical cell lines to milestones in cancer research and health care. The number of publications was derived through access to PubMed (https://www.ncbi.nlm.nih.gov/pubmed/) on 28 May 2019 and applying the following search criteria: (i) (hela [Text Word]) AND cancer [Text Word]; (ii) (raji [Text Word]) AND lymphoma [Text Word]; (iii) (k562 [Text Word]) AND leukemia [Text Word]; and (iv) (nb4 [Text Word]) AND leukemia [Text Word].

Cell Line	Year of Stabilization	Number of Publications in the Cancer Field	Benefit for Public Health Care
HeLa	1953	16,843	Development of the anti-polio vaccine
RAJI	1964	1557	Definition of the mechanisms of infection by Epstein-Barr virus
K562	1976	8001	Development of treatment protocols for chronic myeloid leukemia
NB4	1991	1227	Development of treatment protocols for acute promyelocytic leukemia