Table 2.

Correlation between mRNA expression of NFkB pathway molecules and the antigen-presenting machinery and known regulators of HLA Class I expression, in a cohort of 64 primary UM. r = two-tailed Spearman correlation coefficient. p ≤ 0.05 is considered significant. Bonferroni correction was applied.

Markers	CIITA		NLRC5		IRF1		IRF2		IRF2, pr2		IRF8		TAP1		TAP2		Tapasin		Calreticulin
	r	p	r	p	r	p	r	p	r	p	r	p	r	p	r	p	r	p	r	p
NFkB1	0.212	0.93	0.091	1	0.346	0.05	0.123	1	0.248	0.48	0.236	0.61	0.396	0.01	0.086	1	0.240	0.56	0.342	0.06
NFkB2, pr1	0.261	0.37	0.205	1	0.327	0.08	0.143	1	0.081	1	0.242	0.54	0.409	0.01	0.052	1	0.208	0.99	0.393	0.01
NFkB2, pr2	0.290	0.20	0.191	1	0.238	0.59	0.215	0.89	0.194	1	0.219	0.82	0.320	0.10	0.055	1	0.326	0.09	0.344	0.05
RELA	−0.249	0.48	−0.122	1	−0.180	1	0.145	1	−0.010	1	−0.175	1	−0.206	1	0.118	1	−0.011	1	0.281	0.24
RELB	0.106	1	0.262	0.37	0.449	0.001	0.122	1	0.082	1	0.439	0.001	0.440	0.001	0.444	0.001	0.267	0.33	0.134	1
SPP1, pr1	−0.255	0.42	−0.175	1	−0.394	0.01	−0.119	1	−0.081	1	−0.305	0.14	−0.439	0.001	−0.258	0.40	−0.102	1	−0.081	1
SPP1, pr2	−0.252	0.45	−0.174	1	−0.406	0.01	−0.134	1	−0.067	1	−0.294	0.18	−0.462	0.001	−0.260	0.38	−0.107	1	−0.089	1
PPARγ, pr1	−0.172	1	−0.229	0.68	−0.372	0.02	−0.062	1	0.058	1	−0.394	0.01	−0.443	0.001	−0.299	0.17	−0.259	0.39	0.147	1
PPARγ, pr2	−0.152	1	−0.218	0.83	−0.346	0.05	−0.082	1	−0.020	1	−0.345	0.05	−0.384	0.02	−0.263	0.36	−0.215	0.88	0.138	1
IkBkG	0.022	1	0.215	0.87	0.167	1	0.035	1	0.266	0.34	0.279	0.25	0.084	1	0.298	0.17	0.209	0.98	0.067	1