Table 5.
Correlation between BAP1 staining as defined by immunohistochemical staining and NFkB pathway molecules expression in all tumors for which BAP1 staining was available (n = 55) and again after exclusion of one-third of the tumors with the highest infiltrate, based on CD8 expression (n = 37). One-Way ANOVA was used to calculate the means. p ≤ 0.05 is considered significant.
| Markers | All Tumors (n = 55) | Exclusion of High CD8 Tumors (n = 37) | ||||
|---|---|---|---|---|---|---|
| BAP1 + (Mean n = 25) | BAP1 − (Mean n = 30) | p | BAP1 + (Mean n = 22) | BAP1 − (Mean n = 15) | p | |
| NFKB1 | 9.19 | 9.42 | 0.018 | 9.16 | 9.26 | 0.37 |
| NFKB2-pr1 | 6.98 | 7.19 | 0.001 | 6.98 | 7.16 | 0.014 |
| NFKB2-pr2 | 6.94 | 7.14 | 0.003 | 6.94 | 7.15 | 0.01 |
| RELA | 7.13 | 7.05 | 0.12 | 7.14 | 7.09 | 0.47 |
| RELB | 6.68 | 6.73 | 0.23 | 6.66 | 6.70 | 0.48 |
| SPP1-pr1 | 10.97 | 8.56 | <0.001 | 10.91 | 8.38 | 0.001 |
| SPP1-pr2 | 10.41 | 7.97 | <0.001 | 10.34 | 7.84 | <0.001 |
| PPARγ-pr1 | 8.15 | 7.25 | <0.001 | 8.22 | 7.15 | 0.001 |
| PPARγ-pr2 | 7.00 | 6.51 | 0.001 | 7.03 | 6.46 | 0.003 |
| IkBkG | 7.94 | 7.85 | 0.085 | 7.93 | 7.78 | 0.006 |