Table 4.

Mean expression of mRNA expression of HLA Class I antigens and infiltrating immune cells in relation to Q209L or Q209P mutation on either GNAQ or GNA11. p-values were calculated using the Wilcoxon-Rank sum test. STD = standard deviation.

mRNA Probe	Illumina	D3 Q209L n = 15 Mean ± STD	D3 Q209P n = 6 Mean ± STD	M3 Q209L n = 27 Mean ± STD	M3 Q209P n = 11 Mean ± STD	M3 Q209L versus M3 Q209P p-Value	D3 Q209L versus D3 Q209P p-Value	All M3 versus All D3 p-Value
HLA_A	ILMN 1671054	10.88 ±0.73	10.63 ±0.72	11.85 ±0.79	11.60 ±0.74	0.30	0.79	<0.001
HLA_A	ILMN 2203950	13.35 ±0.80	13.12 ±0.75	14.23 ±0.51	14.16 ±0.55	0.87	0.91	<0.001
HLA_A	ILMN 2186806	10.08 ±1.63	9.39 ±0.93	11.20 ±1.10	11.33 ±1.22	0.70	0.37	<0.001
HLA_B	ILMN 1778401	10.34 ±1.78	9.89 ±1.26	11.99 ±1.34	12.05 ±1.17	1.00	0.97	<0.001
HLA_C	ILMN 2150787	6.34 ±0.66	6.44 ±0.37	6.44 ±0.63	6.74 ±0.77	0.46	0.51	0.38
HLA_C	ILMN 1721113	7.57 ±0.95	7.43 ±0.58	8.16 ±1.19	8.50 ±1.12	0.42	0.97	0.013
HLA_E	ILMN 1765258	11.01 ±1.21	10.81 ±0.61	11.82 ±1.05	11.71 ±0.93	0.63	1.00	<0.001
HLA_F	ILMN 1762861	7.72 ±1.00	7.49 ±0.69	8.58 ±1.13	8.54 ±1.02	1.00	0.67	<0.001
HLA_G	ILMN 1656670	8.32 ±1.16	7.73 ±0.61	9.00 ±0.76	8.96 ±0.69	0.85	0.15	<0.001
CD68	ILMN 1714861	10.39 ±1.16	10.30 ±0.75	11.07 ±0.74	10.99 ±0.87	0.80	0.85	0.008
CD3D	ILMN 2261416	6.92 ±1.32	6.61 ±0.45	7.23 ±1.06	7.41 ±1.29	0.85	0.51	0.033
CD3D	ILMN 2325837	6.94 ±1.39	6.49 ±0.47	7.31 ±1.17	7.44 ±1.29	0.75	0.23	0.016
CD3E	ILMN 1739794	6.49 ±0.39	6.37 ±0.09	6.51 ±0.26	6.60 ±0.35	0.56	0.41	0.19
CD3G	ILMN 1717197	6.60 ±0.36	6.58 ±0.13	6.61 ±0.27	6.60 ±0.33	0.70	0.51	0.77
CD8A	ILMN 1768482	7.10 ±1.59	6.75 ±0.58	7.39 ±1.17	7.71 ±1.43	0.56	0.67	0.061
CD8A	ILMN 1760374	6.50 ±0.46	6.35 ±0.09	6.47 ±0.27	6.57 ±0.52	0.80	0.41	0.25
CD8A	ILMN 2353732	7.00 ±1.63	6.62 ±0.55	7.35 ±1.19	7.64 ±1.44	0.52	0.46	0.019
CD4	ILMN 1727284	6.62 ±0.41	6.51 ±0.21	6.70 ±0.25	6.72 ±0.40	0.90	0.61	0.036