Table 1.
Basic characteristics of included studies. CC, case control; COH, cohort; C, colon; R, rectum; CR, colorectal; NR, not reported; F, feces; T, tumor; S, serum; E, miR-20a expression; OS, overall survival; DFS, disease-free survival; AUROC, area under the receiver operating characteristic curve.
| Author/Year | Study Design | Cancer Pathology | TNM Stage | Biological Specimen | Sample Size (Cancer, Control) | % Female (Cancer, Control) | Measurement Method | Reported Value(s) |
|---|---|---|---|---|---|---|---|---|
| Ahmed 2013 | CC | C | I–IV | F | 40, 20 | 42.5, 50 | Microarray, qPCR | E |
| Azizian 2015 | COH | R | NR | S | 42, 0 | 40.5, NA | qPCR | -- |
| Bovell 2013 | CC | CR | I–IV | T | 381, 381 | 50.7, 50.7 | qPCR | E |
| Brunet 2013 | CC | CR | III–IV | S, T | 42, 26 | 35.7, 50 | Microarray | E |
| Caritg 2016 | COH | C | III–IV | T | 69, 0 | 37.7, NA | qPCR | -- |
| Chen X 2015 | CC | CR | II–III | T | 11, 11 | 18.2, 18.2 | qPCR | E, OS |
| Chen W 2015 | CC | CR | I–IV | S | 100, 79 | 40, 44.9 | qPCR | AUROC, E |
| Cheng 2016 | COH | CR | I–IV | T | 544, 0 | 44.9, NA | qPCR | DFS, OS |
| de Groen 2015 | CC | CR | NR | T | 52, 48 | NR | qPCR | E |
| Hotchi 2013 | COH | R | III–IV | T | 43, 0 | 27.9, NA | qPCR | -- |
| Huang 2017 | CC | CR | NR | S, T | 70, 70 | NR | qPCR | E |
| Luo 2013 | CC | CR | I–IV | S | 180, 244 | 43.3, 57 | qPCR | AUROC, E |
| Molinari 2016 | COH | R | II–IV | T | 108, 0 | 30.6, NA | qPCR | -- |
| Motoyama 2009 | CC | CR | I–III | T | 67, 67 | NR | qPCR | E |
| Ozcan 2016 | CC | CR | II–IV | T | 54, 42 | 37, NR | qPCR | E |
| Pellatt 2016 | CC | CR | NR | T | 1141, 812 | 45.2, 45.7 | qPCR | E |
| Riordan 2012 | CC | R | I–III | T | 17, 17 | NR | qPCR | E |
| Ristau 2014 | COH | CR | I–IV | T | 35, 0 | 40, NA | qPCR | -- |
| Rotelli 2015 | CC | CR | I–III | F, T | 20, 20 | 35, NR | qPCR | E |
| Schetter 2008 | COH | C | I–IV | T | 197, 197 | 38.1, 38.1 | Microarray, qPCR | E, OS |
| Tsuchida 2011 | CC | C | I–IV | T | 13, 9 | NR | qPCR | E |
| Valladares 2011 | COH | CR | I–IV | T | 38, 0 | 34.2, NA | qPCR | DFS, OS |
| Volinia 2006 | CC | C | NR | T | 46, 8 | NR | Microarray | E |
| Wang 2010 | CC | CR | NR | T | 3, 3 | NR | Microarray | E |
| Xu 2015 | CC | CR | NR | T | 30, 30 | 36.7, 36.7 | qPCR | E |
| Yamada 2015 | CC | CR | NR | S | 160, 77 | 33.8, 45.5 | qPCR | E |
| Yantiss 2009 | CC | CR | I–IV | T | 69, 0 | 44.9, NA | qPCR | -- |
| Yau 2016 | CC | CR | I–IV | F, T | 198, 198 | 41.1, 57.6 | qPCR | AUROC, E |
| Zekri 2016 | CC | CR | NR | S | 130, 24 | 38.5, 37.5 | Microarray | AUROC, E |
| Zhang GJ 2014 | COH | CR | I–IV | T | 86, 86 | 38.4, 38.4 | qPCR | E, OS |
| Zhang J 2014 | COH | CR | III–IV | S | 253, 0 | 44.7, 0 | Microarray | -- |
| Zhang JX 2013 | CC | C | II–IV | T | 735, 735 | 41.3, 41.3 | Microarray | -- |