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. 2019 Aug 15;11(8):1187. doi: 10.3390/cancers11081187

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Effects of 4-methylubelliferone (4-MU) on stem cell marker expression in spheroids. Expression of stem cell markers in spheroids from a chemotherapy-resistant primary serous ovarian cancer and OV-90 cells treated with control media or 4-MU (1 mM) for 72 h. HAS2 (a), HAS3 (b), PROM1 (c), ALDH1A1 (d), ABCG2 (e), and CD44 (f). Data are expressed as the median from RNA samples (n = 5–6) from three independent experiments. *, significantly different from control, (p < 0.05, Mann Whitney U test).