Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Aug 2;11(8):1105. doi: 10.3390/cancers11081105

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Expanding High Mobility Group A1 (HMGA1) chromatin functions. HMGA1 participates in the chromatin opening process by displacing histone H1 from chromatin via a competitive mechanism. Once bound to nucleosomes and/or DNA, HMGA1 is involved in the recruitment of transcription factors (TFs) and in the formation of protein platforms for the landing of other chromatin proteins [17,23]. In this work, we provided evidence that in triple negative breast cancer (TNBC) cells HMGA1 could be an essential co-factor for conveying onto chromatin ribosomal protein S6 kinase alpha-3 (RSK2) and CREB-binding protein (CBP) activities.