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. 2019 Aug 6;11(8):1120. doi: 10.3390/cancers11081120

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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LEC-released chemokines promote myeloid-derived suppressor cell (MDSC) recruitment in the lymph nodes via CXCR2. (A) LC cells were injected into the mammary fat pads of nude mice. After one week, mice were treated with vehicle (control) or CXCR2 inhibitor SB225002 for another three weeks. The amount of CD11b⁺/Gr-1⁺ MDSCs in the tumors was investigated by flow cytometry. Scale bar: 50 μm. (B) The number of NK1.1-positive natural killer (NK) cells in the tumors was determined by immunofluorescent staining. Scale bar: 50 μm. (C) The amount of CD11b⁺/Gr-1⁺ MDSCs in the tumor-draining lymph nodes was investigated by flow cytometry. (D) The amount of CD11b⁺/Gr-1⁺ MDSCs in distant lymph nodes was investigated by flow cytometry. * p < 0.05; ** p < 0.01.