Table 4.

Conditioned medium from BMSCs for tissue repair

Conditioned Medium	Animal Models	Outcomes	References
IGF-1, VEGF, TGF-β1 and HGF	Rat periodontal defect model	Contributed to many processes of complicated periodontal tissue regeneration.	[3]
IL-6, IL-8	Rat hind limb ischemia model	Stimulated angiogenesis and tissue repair through an increase in homing of human cord blood-derived endothelial progenitor.	[90]
EGF, bFGF, PDGF, HGF, collagen type 1, and GDF-11	In vivo human test	Stimulated skin rejuvenation by increasing growth and ECM production.	[91]
Collagen types III and I and a high MMPs/TIMPs ratio	Mouse skin excisional wound model	Accelerated healing, with fewer scars compared with control groups.	[92]