IGF-1, VEGF, TGF-β1 and HGF |
Rat periodontal defect model |
Contributed to many processes of complicated periodontal tissue regeneration. |
[3] |
IL-6, IL-8 |
Rat hind limb ischemia model |
Stimulated angiogenesis and tissue repair through an increase in homing of human cord blood-derived endothelial progenitor. |
[90] |
EGF, bFGF, PDGF, HGF, collagen type 1, and GDF-11 |
In vivo human test |
Stimulated skin rejuvenation by increasing growth and ECM production. |
[91] |
Collagen types III and I and a high MMPs/TIMPs ratio |
Mouse skin excisional wound model |
Accelerated healing, with fewer scars compared with control groups. |
[92] |