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Figure depicts pathways that cross-talk with Hh pathway leading to its non-canonical activation. EGF(Epidermal growth factor) signaling pathway activates GLI mediated transcription through pAKT, as well as MAPK activation (shown in brown/red). TGFβ activation is mediated through SMAD2/3/4 complex (shown in blue) and Wnt signaling pathway activation is through b-catenin/TCF-LEF (shown in green).
