Table 1.

Main differences between Xp11 translocation renal cell carcinoma and t(6;11) renal cell carcinoma.

Parameter	Xp11 Translocation RCC	t(6;11) RCC
Clinical
Age distribution	peak: 20–29 years	peak: 30–39 years
Gender	F:M ratio, 1.6:1	F:M ratio, 0.75:1
Behavior	aggressive in 47% of cases	aggressive in 17% of cases
Morphology
features	broad spectrum	usually biphasic
Immunohistochemistry
Cathepsin K	47% positive	94% positive
Melan-A	39% positive	91% positive
HMB45	32% positive	83% positive

RCC: renal cell carcinoma; F: female; M: male.