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. 2019 Jul 31;8(8):806. doi: 10.3390/cells8080806

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Study of cell line response to HSP90 inhibitors according to inhibitor family. Venn diagrams showing overlap of differentially expressed proteins as well as those specific to inhibition with (A) geldanamycin or (B) radicicol derivatives. The analysis of shared proteins following (C) geldanamycin or (D) radicicol treatments was performed with PANTHER software which identified deregulated pathways associated with each HSP90 inhibitor family. The number of proteins involved in each identified pathway is represented on the y axis. PPP= pentose phosphate pathway, TCA cycle = tricarboxylic acid cycle, 5-HT degradation = 5-hydroxytryptamine or serotonin degradation, PDGF pathway = platelet-derived growth factor signaling pathway, SER GLY biosynthesis = serine and glycine biosynthesis, PLP biosynthesis = pyridoxal-5-phosphate biosynthesis, VEGF pathway = vascular endothelial growth factor signaling pathway.