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Model of the KDM3A/KDM4B co-regulatory network. KDM4B is required for the expression of both KDM3A and FOXA1. KDM3A demethylates H3K9me1/me2 marks at EREs, which is required for the recruitment of both KDM4B and FOXA1, which in-turn is required for the recruitment of the ER-transcriptional complex, associated trans-activating chromatin modifications, and the expression of ER-target genes.
